Once the needle is in the skin, gently pull back your syringe plunger to check for blood. If blood comes into the syringe, you have hit a vessel. If you have — this will be very noticeable. This is extremely unlikely to occur following these instructions. If pulling your plunger allows blood to enter the syringe, do not give the injection, as you will give the injection vascularly, which may be dangerous. If this occurs, pull the needle out, and start over with a new injection. If air enters the syringe, you may have gone all the way through the skin, so that the tip of your syringe is drawing in room air.